Study Comparing Conversion From Calcineurin Inhibitors to Rapamune Versus Standard Therapy in Established Renal Allograft Recipients

Wyeth

Status and phase: Completed; Phase 3

Conditions: Kidney Failure; Kidney Transplantation; Graft Rejection

Treatments: Drug: Cyclosporin or tacrolimus

Study type: Interventional

Funder types: Industry

Identifiers

NCT00273871

0468H1-100535

Details and patient eligibility

About

The purpose of the study is to determine the effect of conversion from calcineurin inhibitor based therapy to Rapamune based therapy in patients with mild to moderate renal insufficiency.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 18
• Treatment with a calcineurin inhibitor
• Patients with mild to moderate renal insufficiency

Exclusion criteria

• Patients with acute rejection
• Patients who received a transplant more than 10 years ago

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)