Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain (PROSPECT-CAD)

Montefiore Medicine Academic Health System

Status: Terminated

Conditions: Coronary Artery Disease; Unstable Angina; Acute Coronary Syndrome; Angina Pectoris

Treatments: Procedure: Coronary CT angiography; Procedure: Myocardial perfusion imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT01106612

MMC-07-07-197-a26

Details and patient eligibility

About

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with known coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Enrollment: 7 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient admitted for chest pain / pressure or other suggestive symptoms
• patient has known coronary artery disease (with or without prior revascularization)
• patient has clinical need for non-invasive cardiac evaluation

Exclusion criteria

• evidence of ongoing myocardial infarction or hemodynamic instability
• ischemia on EKG (greater than 1mm ST segment deviation)
• contraindications to CT scanning with iodinated intravenous contrast (including allergies, asthma and renal dysfunction)
• heart rhythm precluding EKG gating
• pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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7 participants in 2 patient groups

Initial coronary CT angiography

Experimental group

Description:

EKG-gated, computed tomography angiography of the coronary arteries during heart rate control

Treatment:

Procedure: Coronary CT angiography

Initial nuclear stress test

Active Comparator group

Description:

Stress radionuclide myocardial perfusion imaging

Treatment:

Procedure: Myocardial perfusion imaging