Study Comparing Liquid and Tablet Buprenorphine Formulations - 5

National Institutes of Health (NIH)

Status and phase: Completed; Phase 3

Conditions: Heroin Dependence

Treatments: Drug: Buprenorphine

Study type: Interventional

Funder types: NIH

Identifiers

NCT00000302

P50-09260-5

NIDA-09260-5

Details and patient eligibility

About

The purpose of this study is to compare liquid and tablet buprenorphine formulations.

Full description

Participants were inducted on either liquid or tablet buprenorphine, in a double-blind, double-dummy manner. They each reached a steady state by the second week, and were scheduled to have blood draws in weeks 3, 4, 7, 8, 11, 12, 15, and 16.

Sex: All

Ages: 21 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

M/F ages 21-50. Opiate dependence according to DSM-IV criteria. Currently enrolled in the outpatient protocol comparing liquid and tablet formulations of Buprenorphine. Agreeable to conditions of study and signed informed consent.

Exclusion criteria

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative-hypnotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.