Study Evaluating The Coadministration of Begacestat And Donepezil

Wyeth logo

Wyeth

Status and phase

Completed
Phase 1

Conditions

Healthy Subjects

Treatments

Drug: Begacestat
Drug: Donepezil plus placebo
Drug: Donepezil

Study type

Interventional

Funder types

Industry

Identifiers

NCT00959881
B1941005
3183A1-1106

Details and patient eligibility

About

This study examines the cardiac effects (effects on the heart) of administering donepezil and begacestat together to healthy subjects.

Enrollment

47 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy
  • Men and women of non-childbearing potential
  • Non smoker or smoker of <10 cigarettes per day and able to refrain from smoking during study
  • 18-50 years old

Exclusion criteria

  • Any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease.
  • Cardiac rhythm abnormalities
  • Family history of cardiac risk factors

Trial design

47 participants in 2 patient groups

Donepezil plus placebo
Experimental group
Treatment:
Drug: Donepezil plus placebo
Donepezil plus begacestat
Experimental group
Treatment:
Drug: Donepezil
Drug: Begacestat

Trial contacts and locations

0

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems