Study of a Polymorphism in Patients With Prostate Cancer

National Cancer Institute (NCI)

Status: Completed

Conditions: Prostate Cancer

Treatments: Genetic: polymerase chain reaction; Genetic: mutation analysis; Genetic: polymorphism analysis

Study type: Observational

Funder types: NIH

Identifiers

NCT00900185

NU-98U2

CDR0000304552

NCI-03-C-0153

Details and patient eligibility

About

RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA.

PURPOSE: This laboratory study is looking at blood samples from patients with prostate cancer and from healthy participants to identify a polymorphism that may help in the study of prostate cancer.

Full description

OBJECTIVES:

Primary

• Determine the incidence of the D104N COL18A1 polymorphism in patients with prostate cancer.

Secondary

• Determine the incidence of this polymorphism in African-American patients with prostate cancer.

OUTLINE: This is a retrospective, multicenter study.

DNA is extracted from preexisting serum samples and polymerase chain reaction is performed to determine the genotype pattern.

PROJECTED ACCRUAL: A total of 500 patients and 250 healthy participants will be accrued for this study.

Enrollment: 750 estimated patients

Sex: Male

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of prostate cancer OR healthy participant

• Patient enrolled on an IRB-approved clinical trial at the National Cancer Institute or Northwestern University, including, but not limited to, any of the following:

  • NCI-99-C-0052
  • NCI-95-C-0178
  • NCI-00-C-003
  • NCI-00-C-0080

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified