Study of A Special Vessel Subtype in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture

Soochow University

Status: Unknown

Conditions: Femoral Neck Fractures

Treatments: Procedure: total hip arthroplasty or proximal femoral nails

Study type: Interventional

Funder types: Other

Identifiers

NCT02750046

SencondSoochowU

Details and patient eligibility

About

RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to study a special vessel subtype in the laboratory may help surgeon learn more about the relationship between bone mineral density (BMD) and a special vessel subtype (type H vessel).

PURPOSE: This research study is looking at changes of a special vessel subtype in bone samples from patients with osteoporotic and nonosteoporotic fracture.

Full description

OBJECTIVES:

Establish type H vessel in bone specimen in patients with hip fracture. Explore the correlation of BMD and type H vessel.

OUTLINE:

Collect human bone specimens from patients with Osteoporotic and Nonosteoporotic Fracture. Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators. Observe the type H vessel in bone slice by immunofluorescence staining. Collect clinical data on these patients including bone mineral density. Investigate the relationship between BMD and type H vessel.

Enrollment: 30 estimated patients

Sex: Female

Ages: 60 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Ages Eligible for Study: 65-75 Years
2. Genders Eligible for Study: Woman
3. Accepts Healthy Volunteers: NO
4. Study Population: Female patients with hip fracture. -

Exclusion criteria

1. Malignancy or benign ovarian cysts
2. Known chronic or systemic diseases
3. Hormone therapy in the previous 3 months
4. Bone metabolism and drug therapy

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

30 participants in 2 patient groups

osteoporotic fractures

Experimental group

Description:

patients with osteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.

Treatment:

Procedure: total hip arthroplasty or proximal femoral nails

nonosteoporotic fractures

Sham Comparator group

Description:

patients with nonosteoporotic fractures, including femoral neck fracture and pertrochanteric fracture. Total hip arthroplasty or proximal femoral nails was needed.

Treatment:

Procedure: total hip arthroplasty or proximal femoral nails