Study of ABT-888 in Combination With Bortezomib and Dexamethasone in Patients With Relapsed Refractory Myeloma

AHS Cancer Control Alberta

Status and phase: Completed; Phase 1

Conditions: Multiple Myeloma

Treatments: Drug: ABT-888/Bortezomib

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01495351

MM11-01

E24055 (Other Identifier)

Details and patient eligibility

About

The combination of PARP inhibitor (ABT-888) with a proteasome inhibitors (bortezomib) have demonstrated significant anti-myeloma effects in preclinical lab and animal studies. The goal of this phase I trial is to evaluate in patients with relapsed or refractory multiple myeloma the safety, toxicity profile and tolerability of ABT-888 (Veliparib) administered on a schedule including twice daily oral dosing for 14 days followed by 1 week rest in combination with standard dosing of Bortezomib.

Full description

This is a dose-finding / dose escalation phase I trial of ABT-888 (Veliparib) in combination with Bortezomib and Dexamethasone in patients with relapsed or refractory multiple myeloma. ABT-888 is given orally (PO) twice daily (every 12 hours) for 14 days in a 21 days cycle.

First dose to be given within 1 hour of Bortezomib on day 1. Planned starting dose is 20 mg PO every 12 hours. Starting dose escalation is planned until an MTD is reached.

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed diagnosis of multiple myeloma.
• Measurable disease, according to the International Myeloma Working Group criteria.
• ECOG performance status 0, 1 or 2.
• Patients must have received prior treatment for MM and have relapsed or progressed on prior therapy; no limit on number of prior treatment regimens, but prior treatment must be completed 2 weeks prior to registration. Prior exposure to Bortezomib is not an exclusion criteria as long as patients did not progress or relapse while receiving or within 3 months of completing trt with bortezomib
• Prior radiation, completed at least 4 weeks prior to registration, is permitted.
• Adequate marrow reserve, liver and renal function

Exclusion criteria

• patients with a history of other malignancies, except: adequately treated nonmelanoma skin cancer, curatively treated in-situ cancer of the cervix, prostate cancer with stable PSA for > 3 years, or other solid tumours curatively treated with no evidence of disease for > 5 years.
• Patients with preexisting grade 2 (or higher) sensory neuropathy or grade 1 sensory neuropathy with neuropathic pain.
• Pregnant or lactating women
• Patients receiving concurrent treatment with other anti-cancer therapy any other investigational agents.
• Active or uncontrolled infections
• Patient with known documented congenital or acquired risk factor for thromboembolic event
• Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

ABT-888/Bortezomib

Experimental group

Description:

Patients will be on a treatment schedule including twice daily oral dosing for 14 days followed by 1 week rest in combination with standard dosing of Bortezomib and Dexamethasone in a 21 days cycle for a total of 14 cycles.

Treatment:

Drug: ABT-888/Bortezomib