Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Fanconi's Anemia

Fairview University Medical Center

Status: Completed

Conditions: Fanconi's Anemia

Treatments: Drug: cyclophosphamide; Procedure: Allogeneic Bone Marrow Transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT00005891

199/15099

UMN-MT-1982-10

UMN-MT-8210

Details and patient eligibility

About

OBJECTIVES:

I. Determine the effectiveness of moderate dose cyclophosphamide and total lymphoid radiotherapy in terms of improving the survival and reducing the morbidity following allogeneic bone marrow transplantation in patients with Fanconi's aplastic anemia.

Full description

PROTOCOL OUTLINE: Patients receive cyclophosphamide IV over 2 hours on day -6 through -3 and total lymphoid radiotherapy on day -1. Patients undergo allogeneic bone marrow transplantation on day 0.

Patients are followed for at least 100 days.

Sex: All

Ages: Under 54 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Diagnosis of severe aplastic anemia with the typical phenotype of Fanconi's anemia: Short stature Hypoplastic radii Skin pigmentation Renal anomalies Chromosomal fragility
• Family history of Fanconi's anemia
• Histocompatible related donor No evidence of excessive in vitro chromosome fragility typical of Fanconi's anemia Normal CBC and bone marrow