Study of Antenatal and Postnatal Data of Anorectal Malformations Diagnosed at Montpellier University Hospital Over a 10-year Period (2010-2020)

University Hospital Center (CHU)

Status: Completed

Conditions: Anorectal Malformations

Study type: Observational

Funder types: Other

Identifiers

NCT05045560

RECHMPL20_0616

Details and patient eligibility

About

Objective :

Anorectal malformations (ARMs) are part of a spectrum of malformations due to an abnormal separation between the urogenital and digestive tracts during embryonic life. The prevalence of ARM is 1/2000 - 1/5000 live births, making it a relatively common malformation.

The impact of an ARM depends mainly on the type of malformation, which can be difficult to evaluate in the antenatal period, and whether it is isolated or associated (50-80%) with other malformations or genetic syndromes. Only 1 to 16% of ARMs are diagnosed in the antenatal period.

The objective of this study is to compare cases of prenatal diagnosis of ARM, cases of postnatal diagnosis of ARM with other antenatal ultrasound abnormalities, and those with normal antenatal ultrasound, in terms of management and functional prognosis, to identify ways to improve prenatal counseling.

Materials and methods :

In this retrospective monocentric study, the investigators have included all fetuses and newborns born between January 2010 and September 2020 with anorectal malformations, diagnosed from postnatal radiological examinations and surgical or autopsy reports at the University Hospital of Montpellier. The Krickenbeck classification was used to classify the ARMs and to assess the functional prognosis.

Enrollment: 98 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• fetuses and newborns born between January 2010 and September 2020 with anorectal malformations
• diagnosed from postnatal radiological examinations and surgical or autopsy reports at the University Hospital of Montpellier.

Exclusion criteria

• foreign-born patient
• anorectal malformation associated with an abdominal wall defect

Trial design

98 participants in 3 patient groups

antenatal diagnosis of anorectal malformation

Description:

Groupe 1 : antenatal diagnosis of anorectal malformation

postnatal diagnosis of anorectal malfiormation with associated anomalies on antenatal ultrasound

Description:

Groupe 2 : postnatal diagnosis of anorectal malfiormation with associated anomalies on antenatal ultrasound

postnatal diagnosis of anorectal malformation with anormal antenatal ultrasound

Description:

Groupe 3 : postnatal diagnosis of anorectal malformation with anormal antenatal ultrasound