Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection

Aarhus University Hospital

Status and phase: Withdrawn; Phase 1

Conditions: Neurosurgery

Treatments: Drug: Linezolid; Drug: Vancomycin; Drug: Teicoplanin

Study type: Interventional

Funder types: Other

Identifiers

NCT00925093

AUH-MGP-AB-CSV-2009-1

Details and patient eligibility

About

Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Over 18 years old
• Already having an external CSF drain
• Scheduled for neurosurgery requiring antibiotic prophylaxis (most commonly placement of an internal drain ("shunt")

Exclusion criteria

• Infection or colonization requiring other than standard prophylactic antibiotics

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 3 patient groups

Vancomycin

Active Comparator group

Description:

Vancomycin is administered intravenously and subsequently measured in cerebrospinal fluid sample

Treatment:

Drug: Vancomycin

Teicoplanin

Active Comparator group

Description:

Teicoplanin is administered intravenously and subsequently measured in cerebrospinal fluid sample

Treatment:

Drug: Teicoplanin

Linezolid

Active Comparator group

Description:

Linezolid is administered intravenously and subsequently measured in cerebrospinal fluid sample

Treatment:

Drug: Linezolid