Study of Antiinflammatory Effects of Detralex (Daflon)

University Hospital Dubrava

Status and phase

Completed

Phase 4

Conditions

Chronic Venous Insufficiency

Treatments

Drug: Detralex

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01654016

Detra-001-Ajd

Details and patient eligibility

About

Aim of the study:

To investigate if there is a differences in expression of inflammatory markers in venous wall and blood among patients treated with Detralex and those not treated with Detralex (control group).

Full description

Chronic venous disease (CVD) represents one of the most common vascular disorder. It's different clinical manifestations (most often seen as varicose veins) can be observed in up to 40% of adult female population and in about 30% of adult males.

Different mechanical and biological factors play role in the process of deterioration of venous wall tone and consequent vein valve disfunction that eventually lead to increase venous pressure . Evidence suggest that inflammation has a central place in this process even from the early stage of CVD.

Usual symptoms of venous insufficiency are pain, leg heaviness, night cramping, itching, and are often accompanied with leg edema. The extent of clinical manifestation may not correlate with patients' symptoms. Treatment of varicose veins encompasses vein surgery (stripping, phlebectomy, radiofrequency and laser ablation), sclerotherapy and compression therapy. Detralex (in some countries registered as Daflon) is an oral flavonoid that consists of 90% micronized diosmin and 10% flavonoids expressed as hesperidin. Several studies showed some beneficial effects of Detralex in alleviating symptoms in patients with CVD. It may be used in conjunction with surgery, sclerotherapy, or compression therapy or it may be the only therapy when other therapeutical modalities are not indicated or not feasable.

Animal studies showed antiinflammatory effects of Daflon in way that Daflon acts favorably on microcirculatory complications by normalizing the synthesis of prostaglandins and free radicals. It decreases bradykinin-induced microvascular leakage and inhibits leukocyte activation, trapping, and migration.

However, by searching the available literature (MEDLINE) we found no study that investigated what are the antiinflammatory effects of flavonoids in humans.

The aim of this study is to investigate if there is a differences in expression of inflammatory markers in venous wall and blood between patients treated with Detralex and those not treated with Detralex (control group).

Enrollment

84 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Chronic venous disease (CEAP 2 and 3) and saphenofemoral insufficiency

Exclusion criteria

Previous deep venous thrombosis
Previous or acute thrombophlebitis of the GSV (confirmed by duplex findings - morphologic changes of the GSV above the knee)
Immunological disorders
Diabetes type I or II,
Severe inflammatory disease: such as Behcet, lupus, Horton and other arteritis, polyarthritis, spondylarthritis or sclerodermia
Recent (less than 3 months) or scheduled non-authorized non-pharmacological treatments:
Sclerotherapy,
Surgical treatment of varicose veins (crossectomy, phlebectomy),
Endovenous treatment (endovenous laser, radiofrequency),
Non-authorized pharmacological treatment in the last 3 months and during the study:
Anti-inflammatory agents (except acetylsalicylic acid at dose 350 mg daily),
Systemic corticosteroids or immunosuppressives,
Venoactive drugs including open label MPFF,
Pentoxifylline
Patients already (at the time of randomization) taking Detralex for symptoms linked to chronic venous disease
Arterial insufficiency (absent pedal pulses or ABI < 0.9)
Any important clinical or laboratory abnormalities
Pregnancy, breastfeeding or wish of becoming pregnant during the study