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Study of ANX007 in Participants With Primary Open-angle Glaucoma

A

Annexon

Status and phase

Completed
Phase 1

Conditions

Open Angle Glaucoma

Treatments

Biological: 5.0mg ANX007
Other: Sham Procedure
Biological: 2.5mg ANX007

Study type

Interventional

Funder types

Industry

Identifiers

NCT04188015
ANX007-GLA-02

Details and patient eligibility

About

This is a double-masked, randomized, sham-controlled study evaluating two dose levels of ANX007 vs sham, administered as repeat Intravitreal (IVT) injections in patients with Primary Open-angle Glaucoma.

Full description

This is a phase 1b, double-masked, sham-controlled study evaluating 2 dose levels of ANX007 administered as 2 IVT injections separated by 4 weeks. Approximately 15-29 subjects will be enrolled. An interim analysis of the initial set of 15 participants may be conducted. Based on this analysis, an additional 10-14 participants may be enrolled at a 1:1 ratio to receive one of the two dose levels.

The primary objective is to evaluate the safety and tolerability of repeat IVT injections of ANX007 in participants with primary open-angle glaucoma. Secondary objectives are to evaluate the anterior chamber fluid pharmacokinetics (PK) of ANX007, PD effect of ANX007 on anterior chamber fluid C1q activity, and immunogenicity. An exploratory objective will evaluate ocular PD effect of ANX007.

Enrollment

17 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Male or female age 18 years, and above.
  2. Diagnosis of primary open-angle glaucoma.
  3. Ability to perform a reliable visual field test in the study eye with a cutoff of 33% for fixation losses and 33% for false-positive response rates.
  4. Intraocular pressure (IOP) <21 mm Hg at screening and Day 1.
  5. The IOP treatment regimen in the study eye should be stable for at least 4 weeks prior to injection, with no change in the IOP treatment regimen anticipated throughout study participation.
  6. Ability to comply with the requirements of the study and complete the full sequence of protocol specified injections, procedures, and evaluations.

Exclusion criteria

  1. Extensive glaucomatous visual-field damage with a mean deviation worse than -18 dB on Humphrey visual field testing.
  2. Any current or prior ocular pathology, other than glaucoma, which could interfere with the conduct of the study including, but not limited to, retinal or optic nerve disease and media opacity in the study eye.
  3. History of intraocular inflammatory or infectious eye disease in the study eye.
  4. Ocular trauma in the study eye within the preceding 6 months.
  5. A history of uncomplicated cataract surgery less than 3 months prior to injection, or trabeculectomy, iridotomy, or other ocular procedures in the study eye that could affect drug distribution and excretion.
  6. Any abnormality preventing reliable tonometry in the study eye.
  7. Concurrent use of glucocorticoid medications administered by any ocular or systemic route. Nasal, inhaled, and dermatologic (if not administered around the eyes) glucocorticoids are permitted.
  8. Receiving monoamine oxidase inhibitor therapy or patient-reported hypersensitivity to any component of apraclonidine, brimonidine, clonidine, phenylephrine, povidone iodine, proparacaine, or ANX007.
  9. Active or history of malignancy within the past 5 years with the exception of curatively treated, basal cell carcinoma.
  10. Previous treatment with another humanized monoclonal antibody, Fab or Fab'2.
  11. History of any autoimmune or neurologic disease.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

17 participants in 3 patient groups

2.5mg ANX007
Experimental group
Description:
1 in every 3 subjects will be randomized to 2.5mg dose of ANX007.
Treatment:
Biological: 2.5mg ANX007
5.0mg ANX007
Experimental group
Description:
1 in every 3 subjects will be randomized to 5.0mg dose of ANX007.
Treatment:
Biological: 5.0mg ANX007
Sham Procedure
Sham Comparator group
Description:
1 in every 3 subjects will have a sham procedure performed instead of receiving ANX007.
Treatment:
Other: Sham Procedure

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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