Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia (PROMISE)

Pasteur Institute

Status: Not yet enrolling

Conditions: Misophonia

Treatments: Other: Exposure to unpleasant sounds; Other: semi-structured interviews; Behavioral: Psychoacoustic test

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06921187

2024-058

2024-A02048-39 (Other Identifier)

Details and patient eligibility

About

The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.

Enrollment: 110 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For all participants

• Obtain oral consent from the participant after receiving information about the study,
• Be 18 years or older on the day of inclusion,
• Be fluent in French (spoken and written),
• Have no known hearing loss, verified by pure tone audiometry.
• Declare that they do not have tinnitus,
• Declare that they do not have hyperacusis, verified by measuring discomfort thresholds.
• Be affiliated to the social security or equivalent scheme.

For participants with misophonia:

• Declare discomfort, reduced tolerance to specific sounds (mouth noises, throat clearing, breathing, etc.).

Exclusion criteria

• Bear the after-effects of an ear infection and/or have a history of an ENT disease that permanently affects hearing or balance (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis),
• Be under guardianship,
• deprived of liberty by judicial or administrative decision, or subject to legal protection.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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110 participants in 2 patient groups

Control group

Active Comparator group

Treatment:

Other: semi-structured interviews

Behavioral: Psychoacoustic test

Misophonia group

Experimental group

Treatment:

Other: semi-structured interviews

Behavioral: Psychoacoustic test

Other: Exposure to unpleasant sounds