Study of Bendamustine/Rituxan Induction Chemotherapy With Revlimid Maintenance for Relapsed/Refractory CLL and SLL

University of Wisconsin (UW)

Status and phase

Completed

Phase 2

Conditions

Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia

Treatments

Drug: Bendamustine

Drug: Rituximab

Drug: Lenalidomide

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00974233

NCI-2011-00646 (Registry Identifier)

HO08405

A534260 (Other Identifier)

H-2009-0087 (Other Identifier)

SMPH\MEDICINE\HEM-ONC (Other Identifier)

RV-CLL/SLL-PI-397

Details and patient eligibility

About

The purpose of this research is to evaluate a new combination of chemotherapy drugs for CLL/SLL using the drugs bendamustine (an intravenous chemotherapy drug), rituximab (an intravenous medication called a monoclonal antibody), and lenalidomide (an anti-cancer pill).

The purpose of this study is to see if giving the chemotherapy pill lenalidomide after treatment with bendamustine and rituximab is able to prolong the period of time before the cancer starts growing again and causing symptoms.

Enrollment

34 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed,CLL/SLL, documented relapsed or refractory disease after at least one prior chemotherapy regimen.
In cases of SLL, patients must have at least one bidimensionally measurable lesion at least ≥1.5 cm measured in one dimension.
ECOG performance status of 0-2 at study entry
Laboratory test results within these ranges: ANC <=1500/μL, Platelet count <= 100,000/μL. Patients with ANC <1500/μL or plt <100,000/μL with splenomegaly or extensive bone marrow involvement as the etiology for their cytopenias are eligible.
creatinine clearance of >60 mL/min as determined by the Cockcroft-Gault calculation.
Total bilirubin <= 2X upper limit laboratory normal (ULN). Patients with non-clinically significant elevations of bilirubin due to Gilbert's disease are not required to meet these criteria.
Serum transaminases AST (SGOT) and ALT (SGPT) <=5x ULN, Serum alkaline phosphatase ≤5 X ULN.
Disease free of prior malignancies for ≥ 2 years with the exception of basal or squamous cell skin carcinoma, carcinoma "in situ" of the breast or cervix, or localized prostate cancer (treated definitively with hormone therapy, radiotherapy, or surgery).
Patients may have received prior therapy with bendamustine or lenalidomide, but must not have disease that is refractory to bendamustine or lenalidomide.
Prior therapy with rituximab is permitted, even in the setting of rituximab refractory disease.

Exclusion criteria

Has received >5 lines of prior therapy for their disease. Re-treatment with an identical regimen does not count as a new regimen.
Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form or comply with the protocol treatment.
Pregnant or breast feeding females. Lactating females must agree not to breast feed while taking lenalidomide.
Prior history or current evidence of central nervous system or leptomeningeal involvement.
Use of any other experimental drug or therapy within 28 days of baseline.
Known hypersensitivity to thalidomide.
The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs.
Known to be positive for HIV or infectious hepatitis, type B or C.