Study of Betatrophin Levels in Patients With Type 2 Diabetes and Gestational Diabetes and Healthy Subjects

Qingdao University

Status: Unknown

Conditions: Gestational Diabetes Mellitus (GDM); Type 2 Diabetes; Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT02025673

Betatrophin-Human

Details and patient eligibility

About

Betatrophin is a newly identified hormone that promotes pancreatic beta cell proliferation, improves glucose tolerance and regulates lipids metabolism. A recent study showed that circulating concentrations of betatrophin doubled in type 1 diabetes. The objective of this study is to investigate the association of serum betatrophin levels with the progression of diabetic retinopathy in patients with type 2 diabetes and the level of betatrophin in gestational diabetes patients and pregnant women.

Full description

200 subjects were recruited in this study and divided into six groups for comparison of the serum betatrophin. 70 healthy subjects and 20 healthy young volunteers were enrolled for investigating the role of betatrophin in energy homeostasis and the circadian rhythm. 50 patients with type 2 diabetes were classified into three groups by the stage of diabetic retinopathy. Rank test was used to analyze the correlation between the progression of diabetic retinopathy and circulating betatrophin. Betatrophin were measured by a commercially available enzyme-linked immunosorbent assay and confirmed via Western Blot.

Enrollment: 200 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes mellitus patients
• Patients with HbA1c >or= 7.0%

Exclusion criteria

• Participation in other investigational Clinical Trial
• Type 1 diabetes mellitus patients
• Patients with history of severe hepatic dysfunction
• Treatment with antifungal agent especially Miconazole
• Patients with active smoking or history of smoking cessation less than 2 months

Trial design

200 participants in 3 patient groups

Healthy Controls

Description:

Healthy subjects as control group.

Type 2 diabetes

Description:

Patients with type 2 diabetes.

Gestational diabetes mellitus

Description:

Patients with gestational diabetes mellitus.