Study of Blood and Tissue Samples From Patients With Larynx Cancer, Pharynx Cancer, or Oral Cavity Cancer

Centre Oscar Lambret

Status: Unknown

Conditions: Head and Neck Cancer

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: Other

Identifiers

NCT00963326

ID-RCB-2008-A00300-55

COL-CARIO

2007-11

INCA-RECF0897

CDR0000635996

Details and patient eligibility

About

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at blood and tissue samples from patients with larynx cancer, pharynx cancer, or oral cavity cancer.

Full description

OBJECTIVES:

Primary

• Characterize, morphologically and molecularly, squamous cell carcinoma of the larynx, pharynx, or oral cavity in patients without high-risk factors, such as alcohol consumption, smoking, or occupation.

Secondary

• Study the impact parameters of morphology, molecular characteristics, and genomics on disease-free survival and overall survival of these patients.
• Study the impact parameters of morphological, molecular, and genomic control in the tumor.
• Assess, in advanced tumors, the risk of heterogeneity of morphological, molecular, and genomic control in the tumor.

OUTLINE: This is a multicenter study.

Blood, tumor tissue, and healthy tissue samples are collected before treatment begins.

Patients are followed up every 3 months for 2 years (additional biopsies may be collected).

Enrollment: 60 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed squamous cell carcinoma of the larynx, pharynx, or oral cavity

• No risk factors of alcohol consumption, smoking, or occupational hazards such as asbestos, hydrocarbons, paints, nickel, stone dust, or wood dust.

  • Must be a life-time non-smoker, not a former smoker

• Measurable disease by RECIST criteria

PATIENT CHARACTERISTICS:

• WHO performance status 0-1
• No other serious concomitant medical conditions precluding general anesthesia
• No psychological, familial, social, or geographical reasons that would preclude follow up

PRIOR CONCURRENT THERAPY:

• Not specified