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Tumors have a systemic immune modifying effect. They affect the immune system similarly to states of chronic inflammation and these effects can:
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CD247 Known also as the zeta chain is important for relaying T-cell induced signal transduction.
Interestingly studies by Baniash and others have demonstrated that this chain is down regulated in states of chronic inflammation and cancer in peripheral blood T cells and also in NK cells However there has not been a prospective study of this marker in cancer and control patients such a study will reveal not only the levels of CD247 in immune cells of cancer patients compared to controls but may reveal the effect of anticancer therapies on CD247 in cancer patients such a study may contribute significantly to our ability to monitor systemic immune system characteristics in cancer patients and help in any further studies of immunomodulation such as vaccination schemes in such patients
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100 participants in 2 patient groups
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Hovav Nechushtan, MD PHD; Moshe sade, BSC
Data sourced from clinicaltrials.gov
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