Study of Blood Platelets in Sickle Cell Disease

Rockefeller University

Status: Withdrawn

Conditions: Sickle Cell Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00226083

RUH IRB # AST-0565-0805

Details and patient eligibility

About

We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.

Full description

Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.

Sex: All

Ages: 7+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults and children > 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy.

Exclusion criteria

• Current hydroxyurea therapy or,
• Hydroxyurea use within the past 3 months
• Blood transfusion or exchange transfusion within the past 3 months
• Current treatment with aspirin or clopidogrel