Study of Blood Samples From Patients With Osteosarcoma

Children's Oncology Group

Status: Completed

Conditions: Recurrent Osteosarcoma; Localized Osteosarcoma; Metastatic Osteosarcoma

Treatments: Other: laboratory biomarker analysis

Study type: Observational

Funder types: NETWORK; NIH

Identifiers

NCT00954473

COG-AOST08B1 (Other Identifier)

U10CA098543 (U.S. NIH Grant/Contract)

AOST08B1 (Other Identifier)

NCI-2011-02192 (Registry Identifier)

Details and patient eligibility

About

This research trial studies blood samples from patients with osteosarcoma. Studying the genes found in samples of blood from patients with osteosarcoma may help doctors identify biomarkers related to the disease.

Full description

PRIMARY OBJECTIVE:

I. Conduct a large-scale candidate gene association study in osteosarcoma (OS) using cases from the national Children's Oncology Group (COG) OS biology study (P9851 and successor study AOST06B1).

SECONDARY OBJECTIVES:

I. Conduct a genome-wide association study (GWAS) of OS. II. Fine-map genomic regions associated with OS to identify putative functional loci.

III. Conduct whole-exome sequencing of germline OS deoxyribonucleic acid (DNA) samples.

IV. Investigate the functional implications of promising genetic variants associated with OS.

OUTLINE:

Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and haplotypes to examine genetic variation, gene-gene interactions, and the population structure.

Enrollment: 1,000 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Blood samples collected from clinical trials COG-P9851 and COG-AOST06B1

Trial design

1,000 participants in 1 patient group

Ancillary-correlative (osteosarcoma genetic risk)

Description:

Blood samples undergo polymorphism analysis of common single-nucleotide polymorphisms and haplotypes to examine genetic variation, gene-gene interactions, and the population structure.

Treatment:

Other: laboratory biomarker analysis