Study of Calcium Metabolism in Teenage Girls With Type 1 Diabetes

University of Rochester

Status: Completed

Conditions: Diabetes Mellitus, Type 1

Treatments: Diagnostic Test: calcium isotope analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03156179

56744

Details and patient eligibility

About

The proposed pilot study will enroll 33 adolescent females with type 1 diabetes for the assessment of whole body calcium metabolism using dual stable calcium isotopes. This is the state of the art technique for assessing calcium metabolism in the body and has been used in both healthy and diseased pediatric populations.

Enrollment: 22 patients

Sex: Female

Ages: 9 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of T1D of at least three years duration
• Female sex
• Age between 9-18 years
• Parental/guardian consent and participant assent
• BMI <99th percentile

Exclusion criteria

• History of metabolic bone disease, chronic renal disease, hepatic disease, celiac, or other malabsorptive disease
• History of any proton-pump inhibitor use within a 6 month period prior to enrollment
• History of oral or inhaled corticosteroid use for ≥ 5 consecutive days within a 6 month period prior to enrollment
• Pregnant or lactating females
• Parents/guardians or participants who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures.

Trial design

22 participants in 1 patient group

Girls with type 1 diabetes

Treatment:

Diagnostic Test: calcium isotope analysis