Study of Carrageenan's Effect on Insulin Resistance in Humans

University Hospital Tuebingen

Status: Completed

Conditions: Insulin Resistance; Diabetes Mellitus, Type 2

Treatments: Dietary Supplement: Carrageenan; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02629705

CGN

Details and patient eligibility

About

The purpose of this study is to determine whether the ingestion of the common food additive carrageenan contributes to insulin resistance and thus to the pathogenesis of type 2 diabetes in humans.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• body mass index (BMI) 18.5 - 29.9 kg/m²

Exclusion criteria

• any chronic illness
• any ongoing medication
• known infections
• known liver disease
• known renal insufficiency
• alcohol consumption over 30 g/d
• shift work

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Group A

Other group

Description:

1. Placebo intervention 2. Assessment block (3 days) 3. Washout-phase of 21-35 days 4. Carrageenan intervention 5. Assessment block (3 days)

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Carrageenan

Group B

Other group

Description:

1. Carrageenan intervention 2. Assessment block (3 days) 3. Washout-phase of 21-35 days 4. Placebo intervention 5. Assessment block (3 days)

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Carrageenan