Study of Complex Intracranial Aneurysm Treatment (SCAT)

Meshalkin Research Institute of Pathology of Circulation

Status

Unknown

Conditions

Intracranial Aneurysm

Treatments

Procedure: Cerebral Revascularization

Procedure: Endovascular Flow-Diversion

Study type

Interventional

Funder types

NETWORK

Identifiers

NCT03269942

SCAT

Details and patient eligibility

About

The investigator expects that endovascular flow-diversion is superior over revascularization by postoperative modified Rankin scale (mRS) in patients with complex intracranial aneurysms.

Full description

Open, prospective, controlled randomized superiority trial is conducted. The hypothesis is that endovascular flow-diversion is better than revascularization in treatment of complex intracranial aneurysms by postoperative modified Rankin Scale (mRS). Sample size was measured by Fisher exact test. Depending on a type of the procedure, the patients are divided into two groups: Endovascular Flow Diversion Procedure (include 55 patients) and Revascularization Procedure (include 55 patients). Randomization is performed by random number generation.The study was approved by Institutional Review Board

Enrollment

110 patients

Sex

All

Ages

Under 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

anterior circulation complex intracranial aneurysm
neck is more than 4 mm wide
dome/neck ratio of aneurysm equals or less than 2:1
age less than 75 years
ability to give informed consent (subject or legally authorized representative)
aneurysm is suitable for treatment to both procedures

Exclusion criteria

subarachnoid hemorrhage less than 30 days ago
contraindications to endovascular treatment
atypical aneurysms (mycotic, flow-related in patients with AVM, traumatic, false)
informed consent refusal