Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis

Alexion Pharmaceuticals

Status and phase

Enrolling

Phase 3

Conditions

PNH

Paroxysmal Nocturnal Hemoglobinuria

Extravascular Hemolysis

Treatments

Drug: Danicopan

Study type

Interventional

Funder types

Industry

Identifiers

NCT06449001

ALXN2040-PNH-302 (Other Identifier)

D7332C00006

Details and patient eligibility

About

The primary objective of this study is to evaluate efficacy of danicopan as add-on treatment to ravulizumab or eculizumab as assessed by hemoglobin (Hgb) change from Baseline at Week 12 in pediatric participants with paroxysmal nocturnal hemoglobinuria (PNH) and clinically significant extravascular hemolysis (CS-EVH).

Enrollment

6 estimated patients

Sex

All

Ages

12 to 17 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Confirmed diagnosis of PNH.
CS-EVH defined by: Anemia: Hgb ≤ 10.5 g/dL, and absolute reticulocyte count ≥ 100 × 109/L
Treated with ravulizumab or eculizumab for at least 12 weeks immediately preceding Day 1, the dose received should be stable during this period, and there should be no anticipated changes in dosage or interval during the first 12 weeks of this study.
all participants must be vaccinated against meningococcal infection from serogroups A, C, W, and Y and serogroup B within 3 years prior to, or at least 14 days prior to Day 1
vaccinated against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae

Exclusion criteria

Platelet count < 30000/μL or there is a need for platelet transfusions.
ANC < 500/μL.
Clinically significant laboratory abnormalities related to liver function, including:
- ALT > 2 × ULN or ALT > 3 × ULN for participants with documented liver iron overload defined by serum ferritin values ≥ 500 ng/mL.
- Direct bilirubin > 2 × ULN, unless, in the Investigator's opinion, is due to hemolysis or Gilbert's syndrome based on medical history.
Current evidence of biliary cholestasis.
Known aplastic anemia or other bone marrow failure that requires HSCT or other therapies, including anti-thymocyte globulin and immunosuppressants unless the dosage of immunosuppressant has been stable for at least 12 weeks before Day 1 and is expected to remain stable through Week 12.
History of a major organ transplant (eg, heart, lung, kidney, liver) or HSCT.
Known or suspected complement deficiency.
Active bacterial or viral infection, a body temperature > 38°C on 2 consecutive daily measures, evidence of other infection, or history of any febrile illness within 14 days prior to first study intervention administration.