Study of Demarcation Line Depth in Transepithelial Versus Epithelium-off Accelerated Cross-linking (AXL) in Keratocouns

Kasr El Aini Hospital

Status: Unknown

Conditions: Progressive Keratoconus

Treatments: Procedure: corneal cross-linking

Study type: Interventional

Funder types: Other

Identifiers

NCT04045626

N28

Details and patient eligibility

About

To assess depth of demarcation line in transepithelial versus epithelium-off accelerated cross-linking in keratoconus patients

Full description

Anterior segment optical coherence tomography "OCT" will be performed to evaluate the corneal stroma for the presence of demarcation line 1 month postoperatively by an independent observer unware of purpose of study

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• progressive keratoconus stage 1-2

Exclusion criteria

• any concomitant ocular disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Transepithelial accelerated cross-linking

Active Comparator group

Description:

Paracel is instilled 1 drop every 1.5 minutes for 4.5 minutes then vibex-xtra is instilled 4 drops at 5.5 minutes followed by 1 drop at 6.5 minutes for a total soak time of 11 minutes followed by ultraviolet-A" UVA" irradiation with intended irradiance of 45mW/cm2 for 2.4 minutes

Treatment:

Procedure: corneal cross-linking

Epithelium-off accelerated cross-linking

Active Comparator group

Description:

Vibex-rapid is instilled every 2 minutes for 10 minutes followed by ultraviolet-A "UVA" irradiation of 30 mW/cm2 for 4 minutes

Treatment:

Procedure: corneal cross-linking