Study of Dengue in Patients With Autoimmune Diseases During the Epidemics of 2020 and 2021 in Reunion Island (MAIDEN)

Centre Hospitalier Universitaire de la Réunion

Status: Not yet enrolling

Conditions: Dengue

Study type: Observational

Funder types: Other

Identifiers

NCT05852977

2022/CHU/24

Details and patient eligibility

About

It is not known whether there is a different clinical profile of dengue in patients with immune system dysfunction. Preliminary data and previous literature suggest that autoimmune diseases, and in particular their treatment, may favour the evolution to severe forms of dengue.

Our research hypothesis is that the clinico-biological presentation of dengue might be different in case of autoimmune disease, either on the side of overactivation (autoimmune and auto inflammatory diseases without treatment) or immunodepression (autoimmune and auto inflammatory diseases under immunosuppressive treatment).

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years
• Patient with autoimmune or autoinflammatory disease
• Confirmed diagnosis of dengue (in 2020 or 2021): serological test, antigenic test or PCR test to confirm the diagnosis according to current criteria

Exclusion criteria

• minor
• opposition to the re-use of data
• patient not followed in Reunion
• protected adult (guardianship or curatorship) or under legal protection