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Study of Effects of L-Arginine in Colitis and Colon Cancer

Vanderbilt University Medical Center logo

Vanderbilt University Medical Center

Status

Completed

Conditions

Colon Cancer
Ulcerative Colitis

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT01091558
3R01AT004821-02S1 (U.S. NIH Grant/Contract)
090943

Details and patient eligibility

About

The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.

The evaluation of colon tissue, blood, urine, diet, health history, and symptoms will help us learn more about L-Arginine and ulcerative colitis. The investigators believe these studies will provide new insights into the treatment for Inflammatory Bowel Disease (ulcerative colitis) and nutritional needs. The investigators plan to enroll 200 participants in this study over the next two years.

Full description

Amino acids are being measured in colon tissues and in serum by high performance liquid chromotography (HPLC). Cytokines and chemokines are being measured in colon tissues and in serum by Luminex assay. Cytokines and chemokines are also being measured in colon tissues by real-time polymerase chain reaction (PCR) analysis of mRNA expression.

Enrollment

204 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 18 years of age or older
  • Colonoscopy for one of the following: clinical indications, disease assessment, or surveillance for dysplasia (as in ulcerative colitis)
  • Screening for cancer

Exclusion criteria

  • refusal to participate
  • age less than 18 years at time of colonoscopy

Trial design

204 participants in 2 patient groups

Colonoscopy
Description:
Healthy volunteer who is having a screening colonoscopy
Ulcerative Colitis
Description:
Patients with confirmed ulcerative colitis who are scheduled for endoscopy for medical reasons.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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