Study of Efficacy of Induction Chemotherapy With Gemcitabine and Carboplatin for Operable Non-small-cell Lung Cancer Before Surgery

Hospital Authority, Hong Kong

Status and phase: Unknown; Phase 2

Conditions: Lung Neoplasms

Treatments: Drug: gemcitabine, carboplatin; Procedure: surgery

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00563160

B9E-IH-O333

(193-h)in QE/EC/I

HARECCTR0500015

000904

Details and patient eligibility

About

To study the activity of chemotherapy with Gemzar-carboplatin in the preoperative setting for operable stages of non-small-cell lung cancer and to identify novel molecular markers correlated with chemosensitivity and prognosis

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Histologically or cytologically proven, newly diagnosed primary bronchogenic non-small cell lung cancer
• Measurable or evaluable tumour on chest X-ray or CT scan.
• No multiple ipsilateral or contralateral parenchymal tumours
• Stage I(exceptT1N0),II,IIIa disease as shown by PET-CT

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)