Study of ENP-501 in Peanut-Allergic and Non-Allergic Participants

N-Fold, LLC

Status and phase

Not yet enrolling

Phase 2

Phase 1

Conditions

Peanut Allergy

Treatments

Drug: ENP-501

Drug: Placebo

Study type

Interventional

Funder types

NETWORK

Industry

Identifiers

NCT07117669

ENP-501-001

Details and patient eligibility

About

This is a Phase 1/2 study to evaluate the safety and clinical activity of ENP-501 in non-peanut allergic (NPA) healthy participants and participants with an established peanut allergy (PA)

Enrollment

68 estimated patients

Sex

All

Ages

14 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Part 1:

14-50 years of age (inclusive)
Otherwise medically healthy and able to participate in the study
Able to perform spirometry testing in accordance with the American Thoracic Society (ATS) guidelines (2019)
All women of child-bearing potential, agree to either abstain from sexual activity or agree to use an adequate method of contraception for the duration of the study and for 30 days after the last dose of investigational product
Signed and dated written informed consent from the participant and/or parent or guardian
Signed and dated assent from participant under 18 in accordance with local IRB regulations
Willing and able to avoid peanut and peanut contaminants for the duration of the trial

Part 1 Cohort 1 only (NPA Participants)

No known clinical history of peanut allergy with regular exposure to peanuts in daily life, i.e ingests peanuts without symptoms
Negative Skin Prick Test (SPT) (wheal diameter of <3 mm) to peanut

Part 1 Cohort 2 only (PA Participants)

A documented clinical history of peanut allergy, which includes the development of symptoms (e.g., urticaria, flushing, rhinorrhea and sneezing, throat tightness or hoarseness, wheezing, vomiting) verified by a physician
At least two of the three following requirements:
1. Positive Skin Prick Test (SPT) (wheal diameter of ≥ 8 mm) to peanut
2. An elevated serum peanut specific IgE level ≥ 7 kUA/L (ImmunoCAP®)
3. An Ara-h2 IgE level of ≥ 2 kUA/L (ImmunoCAP®)

Part 2:

14 to 50 years of age (inclusive)
A documented clinical history of peanut allergy, which includes the development of symptoms (e.g., urticaria, flushing, rhinorrhea and sneezing, throat tightness or hoarseness, wheezing, vomiting) verified by a physician
At least two of the three following requirements at screening:
1. Positive SPT (wheal diameter of ≥ 3 mm) to peanut
2. Serum peanut-specific IgE level ≥ 0.7 kUA/L (ImmunoCAP®)
3. An Ara-h2 IgE level of ≥ 0.5 kUA/L (ImmunoCAP®) within 1 year of enrollment
Participant must be willing and able to complete a DBPCFC at screening and EOT (24-hours after last dose) and experience dose-limiting symptoms at or before the 300 mg challenge dose of peanut protein during a Double Blind, Placebo Controlled Food Challenge (DBPCFC) conducted in accordance with Practical Issues in Allergology, Joint United States/European Union Initiative (PRACTALL) guidelines
Otherwise medically healthy and able to participate in the study
Able to perform spirometry testing in accordance with the ATS guidelines (2019)
All women of child-bearing potential, agree to either abstain from sexual activity or agree to use an adequate method of contraception for the duration of the study and for 30 days after the last dose of investigational product
Signed and dated written informed consent from the participant and/or parent or guardian
Signed and dated assent from participant under 18 in accordance with local IRB regulations
Willing and able to avoid peanut and peanut contaminants for the duration of the trial

Exclusion criteria

History of severe anaphylactic event requiring mechanical ventilation or use of intravenous (IV) vasopressor drugs
Clinically significant screening electrocardiogram (ECG) abnormality or corrected QTcF >/= 450 msec at Screening
FEV1 value < 80% predicted at Screening
Any hospitalization in the past year for asthma, >1 course of oral steroids for asthma in the past 6 months, or any emergency room visit in the past 6 months for asthma
Poorly controlled atopic dermatitis
Eosinophilic gastrointestinal disease
Use of oral or IV corticosteroids within 30 days of Screening
Use of tricyclic antidepressants within 6 months of Screening
Inability to discontinue antihistamines for at least 5 half-lives before skin testing
Use of omalizumab or other immunomodulatory therapy (not including corticosteroids) or biologic therapy within one year of Screening
Use of any food allergen-specific or other non-traditional form of allergen immunotherapy within one year of Screening
Use of immunosuppressive drugs within 30 days of Screening
Use of ß-blockers (oral)
Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease by history, physical examination, and/or laboratory studies including urinalysis
Pregnant or breast-feeding (if female)
Behavioral, cognitive, or psychiatric disease that in the opinion of the Investigator affects the ability of the participant to understand and cooperate with the study protocol
Known allergy to inactive ingredients of investigational product (active or placebo)
Participation in another interventional clinical trial within 30 days of Screening or within 5 half-lives of the other IP
Residing at the same address as another participant in this or any peanut immunotherapy study