Study of Eye Movements (EYE) as Early Markers of Brain Dysfunction (BRAIN) in Parkinson's Disease (PARK) (eyebrainpark)

Grenoble Alpes University Hospital Center (CHU)

Status: Unknown

Conditions: Parkinson Disease

Treatments: Other: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT04212637

38RC18.214

Details and patient eligibility

About

Identify the neural bases of eye movements during visual tasks and their dysfunction at early stages of Parkinson disease (de novo).

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for all:

• Visual acuity normal or corrected to normal
• Affiliation to a social security scheme (copy of the vital card in support)
• Signed informed consent
• Medical examination according to the participation in the MRI examination
• MMSE score> 23/30

For Parkinson patient:

• Diagnosis of Parkinson's disease
• Presence of asymmetric bradykinesia and rest tremor and / or stiffness
• Hoehn & Yahr Stadium I-II / V

Exclusion Criteria for all:

• Unprotected Majors unable to express their consent
• Protected Major (Persons mentioned in Articles L1121-5,6 and 8 of the public health code)
• Significant hearing or motor impairment
• Past or present neuropsychiatric pathology (except benign epilepsy)
• Taking narcotics and / or drugs for neurocognitive purposes
• Existence of a severe condition in general (cardiac, respiratory, hematological, renal, hepatic, cancerous)
• Any other neurodegenerative pathology or treatment that may affect the oculomotor control

For Parkinson patient:

• Treatment for Parkinson's disease (except the inhibitors of monoaminoxidase B or MAO-B, such as selegiline and rasagiline).

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Healthy Volunteers

Experimental group

Description:

MRI exam

Treatment:

Other: MRI

Parkinson patient

Experimental group

Description:

MRI exam

Treatment:

Other: MRI