Study of Factors Influencing Post-stroke Dementia (strokdem)

University Hospital, Lille

Status: Completed

Conditions: Dementia; Cerebrovascular Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT01330160

2008_42/0907

2008/API1901 (Other Grant/Funding Number)

2009-A00141-56 (Other Identifier)

Details and patient eligibility

About

If the risk of dementia occurrence after stroke is well known, few data exist about the factors influencing positively or negatively the developement of cognitive disorders or dementia. The aim of the study is so to determine prospectively the clinical, biological, lesional and pharmacological factors associated with post-stroke dementia by the long-term follow-up of a stroke patient cohort.

Full description

The STROKDEM study is based on the 5-year prospective follow-up of a population of 1100 stroke patients without dementia. At inclusion in the cohort, main antecedents and risk factors, previous treatment and lifestyle, initial severity and etiology are recorded. Biological samples (for standard ans specialized analyses) and MRI are performed at 72h after stroke occurrence. Thereafter, patients are regularly (6 months, 12 months, 36 months, 60 months) examined for clinical and cognitive assessment with biological samples and Magnetic Resonance Imaging. Patients with dementia will be compared to patients without stroke to identify, by logistic regression analysis and Cox model, the factors associated with dementia occurrence.

Enrollment: 229 patients

Sex: All

Ages: 40 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients > 40 years olds
• hemispheric stroke
• stroke dating from less 72h
• IQ-code < 64
• patient (or his family) given an informed consent

Exclusion criteria

• non hemispheric stroke
• malformative intracranial hemorrhage
• traumatic intracranial hemorrhage
• subarachnoidal hemorrhage
• contra-indication to MRI
• patients unable to answer to cognitive battery

Trial design

229 participants in 1 patient group

cohort of stroke patients

Description:

patients, over 40 years old and without dementia, displaying an hemorrhagic or an ischemic stroke, with a sus-tentorial localization, and included 72h before the onset of symptoms