Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

National Center for Research Resources (NCRR)

Status: Completed

Conditions: IGA Glomerulonephritis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00004305

OSU-94H0338

199/11791

Details and patient eligibility

About

OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N).

II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.

Full description

PROTOCOL OUTLINE:

Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• IgA glomerulonephritis