Study of Genetic Polymorphisms in Thai HIV-1 Infected Patients on SQV/r

The HIV Netherlands Australia Thailand Research Collaboration

Status: Completed

Conditions: HIV Infections

Treatments: Genetic: identify genetic polymorphism in Thai HIV infected

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00476502

HIV-NAT 031

Details and patient eligibility

About

Study of genetic polymorphisms of CYP #A and MDR-1 genes in Thai HIV-1 infected patients on saquinavir/ritonavir.

Full description

Genetic polymorphisms will be investigated by polymerase-chain reaction (PCR) and drug levels of saquinavir will be determined by high phase liquid chromatography with UV-detected (HPLC).

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HIV-infected persons who have been enrolled in the Staccato study
• On low-dose ritonavir boosted saquinavir at the time blood samples are collected

Exclusion criteria

• Inability to understand the nature and extent of the study and the procedures required

Trial design

250 participants in 1 patient group

1

Description:

patients involved in structured interruption therapy

Treatment:

Genetic: identify genetic polymorphism in Thai HIV infected