Study of Gut Microbiome and Colorectal Tumors

NYU Langone Health

Status: Completed

Conditions: Sessile Serrated Adenoma; Hyperplastic Polyp; Serrated Polyp; Colorectal Cancer

Treatments: Diagnostic Test: Mobio PowerSoil DNA Isolation Kit

Study type: Observational

Funder types: Other

Identifiers

NCT03297996

11-01377

Details and patient eligibility

About

Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.

Full description

Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. A relationship between the human gut microbiota and colorectal cancer has been shown; however, its relationship to the different early precursors of colorectal cancer is understudied. This study tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types.

Enrollment: 540 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both men and women who have visited a gastroenterologist or surgeon, aged 18 or older will be included in this study.
• Both men and women residents in the United States, aged 18 or older will be included in this study.

Exclusion criteria

• Women who are pregnant will be excluded from participating in this study
• Subjects on ongoing antibiotic therapy will be excluded from participating in this study.

Trial design

540 participants in 2 patient groups

SIT

Description:

Centers for Disease Control and Prevention (CDC) Study of In-home Tests for Colorectal Cancer (SIT)

Treatment:

Diagnostic Test: Mobio PowerSoil DNA Isolation Kit

NYU

Description:

New York University (NYU) Human Microbiome and Colorectal Tumor study

Treatment:

Diagnostic Test: Mobio PowerSoil DNA Isolation Kit