Study of Heat and Intravenous Fluids for Exogenous Rewarming (SHIVER)

Stanford University

Status: Completed

Conditions: Hypothermia

Treatments: Other: Warmed perfusion pads; Other: Warmed IV fluids

Study type: Interventional

Funder types: Other

Identifiers

NCT02339103

31036

Details and patient eligibility

About

The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with either shivering alone, warmed iv fluids (IVF), or water perfusion pads applied to the hands and feet. The investigators hypothesize that both heated IVF and water perfusion pads to the arteriovenous anastomoses (AVAs) will prove to provide significantly superior rewarming rates than shivering alone.

Enrollment: 8 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Any healthy male or female over 18 years of age

Exclusion criteria

• No heart/blood pressure/cholesterol medications.
• No history of Raynaud's disease or any other condition (including asthma) that could be aggravated by cold-water immersion

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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8 participants in 3 patient groups

Shivering only

No Intervention group

Description:

Pt placed in sleeping bag and warmed by shivering only

Warmed IV fluids

Experimental group

Description:

2 Liter of 42 degree celsius normal saline

Treatment:

Other: Warmed IV fluids

Warmed perfusion pads

Experimental group

Description:

Warmed perfusion pads placed to palms and soles to rewarm through arteriovenous anastomoses

Treatment:

Other: Warmed perfusion pads