Study of Hypoxia Measured in F-Miso PET/Scan and MRI in Patients With Squamous Cells Carcinoma (HYPONECK)

Centre Henri Becquerel

Status and phase: Unknown; Phase 2

Conditions: Squamous Cell Carcinoma of the Oropharynx

Treatments: Drug: F-Miso PET scan coupled with MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT04031534

CHB16.03

Details and patient eligibility

About

Hypoxia imaging has not been studied extensively by combining PET and MRI data. Few studies performed the double imaging and none associated anatomopathology with it . This study will use a rigorous methodology through the production of PET/MRI images at the same time by transferring the patient directly from PET to MRI. In addition, the population, unlike other studies, will include preoperative patients with 24-hour surgery for hypoxia imaging by obtaining additional data through specific immunohistochemical analysis of hypoxia.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with squamous cells carcinoma of oropharynx
• Age Superior to 10 years old
• Male or Female
• measurable target according RECIST criteria

Exclusion criteria

• -Other histologic cancer than squamous cells carcinoma of oropharynx
• No measurable target
• Presence of metastasis

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Measure of hypoxia by F-Miso PET scan and RMI

Experimental group

Description:

Patient will undergo F-Miso PET scan and MRI to detect hypoxia. Imaging will be correlated with immunohistochemistry on tumour biopsy

Treatment:

Drug: F-Miso PET scan coupled with MRI