Study of Immune Responses to Influenza Vaccination

University of Pennsylvania

Status and phase: Enrolling; Phase 4

Conditions: Influenza Vaccination

Treatments: Biological: Influenza vaccination

Study type: Interventional

Funder types: Other

Identifiers

NCT03346772

820590

Details and patient eligibility

About

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

Enrollment: 75 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Community-dwelling adults able to provide consent who need influenza vaccination for standard of care

Exclusion criteria

• febrile illness at time of vaccination
• active malignancy
• use of immunosuppressing medications
• blood donation in the past 60 days
• influenza vaccinated during the preceding 6 months
• allergic reactions to influenza vaccination

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

75 participants in 1 patient group

Influenza vaccination cohort

Experimental group

Description:

Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Treatment:

Biological: Influenza vaccination