Study of Immunosuppression Biomarkers Acquired in Patients Hospitalized in Intensive Care Unit (IMPRIM)

Rennes University Hospital

Status

Completed

Conditions

Patient Hospitalized in Intensive Care Unit

Treatments

Other: blood sample

Study type

Observational

Funder types

Other

Identifiers

NCT02881268

35RC15_9903_IMPRIM

Details and patient eligibility

About

Open-label, non-randomized, prospective, single center, observational, translational study

Full description

The aim of this trial is to study immunosuppression biomarkers in patients hospitalized in intensive care unit in comparison to non-septic patients.

Prevalence of immunosuppression acquired in intensive care unit will be studied and patients most likely to develop nosocomial infection will be early identified

Enrollment

44 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient older than 18 years old
Patient hospitalized in intensive care unit for any reason
Patient with infection started less than 5 days before admission
Patient with mechanical ventilation or not
Patient with arterial catheter for an invasive monitoring of blood pressure
Patient informed about the study protocol and approved to participate.
Patients hospitalized for a severe bacterial infection (severe sepsis or septic shock)
Patient hospitalized for a non-infectious disease

Exclusion criteria

Pregnancy
Advanced immunosuppression defined by proved humoral or cellular impairment by continuous administration of steroids at any dose since more than one month before hospitalization, transplantation, radiotherapy or chemotherapy in the preceding year
Initiation of an immunosuppressive therapy as chemotherapy, cyclophosphamide or high dose corticotherapy (>0.5mg/kg/day)