Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus (LICHENVIR)

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: Lichen Planus, Oral

Treatments: Biological: buccal cavity sample

Study type: Interventional

Funder types: Other

Identifiers

NCT02276573

14-AOI-02

Details and patient eligibility

About

Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied. The erosive form, painful and debilitating is characterized by erosive areas, ulcerated on an erythematous base with or without a keratinocyte lichenien network.

The literature data moving towards an autoimmune origin, but the pathophysiological mechanisms of OLP remain unknown.

This project represents the first part of a comprehensive project to examine the oral pathogenesis of different viruses (Herpes and papillomavirus HPV) and centered on Epstein-Barr Virus (EBV).

Enrollment: 13 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient ≥ 18 years
• Clinical and/or histological diagnosis of erosive or atrophic OLP
• No signs of severe dysplasia at the sampling

Exclusion criteria

o immunosuppressive or anti-inflammatory therapies at the inclusion

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 1 patient group

Oral lichen planus disease

Experimental group

Description:

buccal cavity sample

Treatment:

Biological: buccal cavity sample