Study of Late-foetal Human Organ Development

University College London Hospitals NHS Foundation Trust (UCLH)

Status: Enrolling

Conditions: Congenital Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT04661059

253088

Details and patient eligibility

About

Knowledge about abnormal organ development is important to understand pathology and to develop novel treatment approaches for individuals with congenital and acquired disease. Most of our current understanding is based on examination of tissues from the embryo and early fetus, collected from women undergoing termination of pregnancy in the first trimester (third) of pregnancy. There is very little known about normal and abnormal organ development from a developmental perspective during the crucial last two-thirds of pregnancy when much remodelling of fetal tissues occurs. We aim to collect tissue from a variety of developing fetal organs in the last two-thirds of pregnancy from women who decide to undergo a termination of pregnancy and who wish to undergo a clinical fetal postmortem (PM) examination.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥18 years old pregnant women who attend the Fetal Medicine Unit for concerns about a fetal abnormality where they decide to proceed to termination of pregnancy

Exclusion criteria

• Screening labs positive for maternal HIV, Hepatitis B and Hepatitis C, Chlamydia and Herpes.
• Subject unable to make an informed decision about termination of pregnancy.