Study of Metformin Pharmacogenetics in Twins

University of Southern Denmark (SDU)

Status and phase: Completed; Phase 1

Conditions: Type 2 Diabetes

Treatments: Drug: Metformin

Study type: Interventional

Funder types: Other

Identifiers

NCT01869621

2012-005179-15 (EudraCT Number)

AKF-383

Details and patient eligibility

About

The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.

Enrollment: 34 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-40 years
• Both twins has to be included
• Dizygotic twin pairs has to be same sex
• Informed consent given
• Healthy condition

Exclusion criteria

• Chronical/daily alcohol abuse
• Hypersensitivity to metformin
• Ingestion of drugs containing topiramate or x-ray contrast fluids
• For women: Positive pregnancy test/breastfeeding at the beginning of the trial. No use of safe anticonceptives

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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34 participants in 1 patient group

Metformin

Experimental group

Description:

6 days treatment with metformin

Treatment:

Drug: Metformin