Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD (EXHALBIO)

Centre Hospitalier Intercommunal Creteil

Status: Enrolling

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: collection of human exhalation

Study type: Observational

Funder types: Other

Identifiers

NCT05437198

EXHALBIO

Details and patient eligibility

About

COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.

a second collection for the year +1 will be made, at the same time (between October and March).

Full description

The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies.

After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician.

A collection of the exhalation will also be carried out by the clinical study technician.

Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status

Enrollment: 240 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

For COPD:

• Patients with chronic obstructive pulmonary disease
• Age: over 18

For non-COPD

• Absence of chronic obstructive pulmonary disease
• Age: between 18 and 30 years old and between 45 and 70 years old

Exclusion criteria

• Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants)
• Person under guardianship or curatorship
• Pregnant or breastfeeding women
• Person unable to express his/her opposition, person deprived of liberty
• Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)

Trial design

240 participants in 2 patient groups

Chronic Obstructive Pulmonary Disease (COPD)

Description:

Patients with chronic obstructive pulmonary disease will be recruited from the pulmonology or occupational pathology department. They are either active smokers or ex-smokers. They are over 18 years old

Treatment:

Other: collection of human exhalation

NO-Chronic Obstructive Pulmonary Disease

Description:

The no-COPD are controls followed in chi créteil for another pathology. They are between 18 and 30 years old and 45 and 70 years old. They are either: Ex-smoker Active smoker Non-smoker

Treatment:

Other: collection of human exhalation