Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest

Centre Hospitalier Universitaire, Amiens

Status: Unknown

Conditions: Carotid Plaque; miRNAs

Treatments: Other: Comparing the expression of miRNAs

Study type: Observational

Funder types: Other

Identifiers

NCT03149406

PI2012_843_0019

Details and patient eligibility

About

Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world

Full description

Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world. The constitution of the atheroma plaque is linked to the deregulation of several biological phenomena, including angiogenesis, adipogenesis, inflammatory response, lipid metabolism and oxidative stress. In addition to its anatomical and physiological characteristics, the notion of plate stability is of paramount importance for clinical implications. This stability depends largely on the biological composition of the plate. A vulnerable or unstable plaque often has a large lipid body consisting of foam cells (macrophages laden with oxidized LDL) with a thin fibrous screed consisting of smooth muscle cells (CML), collagen fibers and extracellular matrix. This plaque is also made up of numerous inflammatory cells including macrophages, rich vascularization and intraplate hemorrhage. Although the cell composition of the unstable plate is still relatively established, its molecular analysis remains little known.

The benefit of carotid surgery in asymptomatic patients with stenosis greater than 70% is increasingly controversial given the moderate risk of spontaneous stroke under optimal medical treatment. This annual average risk is less than 5%. Thus, the discovery of an original and innovative biomarker, predictive of plate rupture, would define the patients most at risk, who benefit most from this surgery.

Enrollment: 245 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any adult with a carotid thrombo endarterectomy,
• affiliated to a social security scheme,
• informed of the study and not opposed to it.

Exclusion criteria

• Any person benefiting from an iterative carotid surgery,
• or refusing to participate in the study,
• or not being able to express its consent.

Trial design

245 participants in 2 patient groups

Symptomatic patients

Description:

in the department with carotid plaque Comparing the expression of miRNAs

Treatment:

Other: Comparing the expression of miRNAs

Asymptomatic patients

Description:

in consultation with carotid plaque Comparing the expression of miRNAs

Treatment:

Other: Comparing the expression of miRNAs