Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

Cairo University (CU)

Status: Completed

Conditions: Hypersensitivity Pneumonitis; Nasal Mucosal Disorder

Treatments: Procedure: nasal endoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT05723796

MD-138-2021

Details and patient eligibility

About

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa.

Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

Enrollment: 40 patients

Sex: All

Ages: 29 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all patients with clinical and radiological features of HP

Exclusion criteria

• respiratory failure
• patients on anticoagulants

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

40 participants in 1 patient group

chronic HP patients

Experimental group

Treatment:

Procedure: nasal endoscopy