Study of Opioid Immunosuppressive Effects

Sun Yat-sen University

Status: Unknown

Conditions: Opioid Abuse or Dependence

Study type: Observational

Funder types: Other

Identifiers

NCT01881802

01

Details and patient eligibility

About

This trial aims to investigate the effects of opioid-inducing immune suppression on opioid drug abused patients. The methods of the investigators research mainly includes the expression of morphine-related miRNAs in peripheral blood mononuclear cells and cytokine in plasma.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• subjects were excluded if they had a chronic systemic illness (cardiac, renal, pulmonary, hepatic, endocrine, metabolic, or autoimmune disorders) or
• a major psychiatric disorder or
• if they were abusing substances other than heroin (as determined by urine drug test result). For women, pregnancy was also a reason for exclusion.

Exclusion criteria

• Control subjects with no history of drug or alcohol abuse were also excluded if they had
• major medical or psychiatric disorders

Trial design

50 participants in 2 patient groups

morphine or heroin dependence patients

normal control group