Study of Palifosfamide-tris in Combination With Doxorubicin in Patients With Front-line Metastatic Soft Tissue Sarcoma (PICASSO III)

Alaunos Therapeutics

Status and phase

Completed

Phase 3

Conditions

Soft Tissue Sarcoma

Treatments

Drug: doxorubicin in combination with palifosfamide-tris

Drug: doxorubicin in combination with placebo

Study type

Interventional

Funder types

Industry

Identifiers

NCT01168791

IPM3001

Details and patient eligibility

About

This is an international, randomized, double-blind, placebo-controlled trial to evaluate the clinical efficacy of palifosfamide-tris administered with doxorubicin in combination, compared with doxorubicin administered with placebo in front-line patients diagnosed with metastatic soft tissue sarcoma (STS).

Enrollment

447 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

To be eligible, each patient must meet EACH of the following criteria:

Age ≥18 years.
Documented soft tissue sarcoma
Metastatic disease for which the patient has not received any prior treatment, and for whom treatment with doxorubicin is considered medically acceptable.
ECOG Performance Status of 0, 1 or 2
Adequate bone marrow and organ function based on the results of protocol- specified laboratory tests
Male and female patients must agree to use a highly reliable method of birth control during study participation.
Able to provide informed consent

To be eligible, each patient must meet NONE of the following criteria:

Specific sarcoma histological subtypes including GIST and Ewing's sarcoma.
Systemic therapy for the treatment of metastatic sarcoma, prior to or during the study. However, patients may have received neo-adjuvant/adjuvant Gemzar and Taxotere chemotherapy for their primary sarcoma, prior to the development of metastatic disease
Any prior anthracycline use.
Known allergy to any of the study drugs or their excipients.
Any unstable or clinically significant concurrent medical condition that would, in the opinion of the investigator, jeopardize the safety of a patient and/or their compliance with the protocol, based on screening tests, physical examination and medical history (as specifically defined in the clinical protocol).
Myocardial dysfunction defined as left ventricular ejection fraction (LVEF) <50%.
Documented metastases to brain or meninges.
Any malignancy other than sarcoma within the last 5 years prior to screening, with the exception of cervical carcinoma in situ, basal cell carcinoma, or superficial bladder tumors (Ta, Tis, or T1) that have been successfully and curatively treated with no evidence of recurrent or residual disease.
Currently pregnant or nursing.
Radiotherapy with curative intent within 4 weeks of first dose of study drug.