Study of Panobinostat in Patients With Neuroendocrine Tumors

University of Wisconsin (UW)

Status and phase

Terminated

Phase 2

Conditions

Neuroendocrine Tumors

Treatments

Drug: panobinostat (LBH589)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00985946

2014-1298 (Other Identifier)

CLBH589BUS38T (Other Grant/Funding Number)

A534260 (Other Identifier)

SMPH\MEDICINE\HEM-ONC (Other Identifier)

NCI-2011-00320 (Registry Identifier)

2010-0050 (Other Identifier)

CO08209

Details and patient eligibility

About

This summary will use Panobinostat (LBH589) in patients with neuroendocrine tumors to see how the patient's tumor responds to panobinostat. Additionally, this study will examine how long it takes neuroendocrine tumor patient's cancer to progress while taking the drug and examine the overall survival of patients using panobinostat. Also, the study will examine the toxicity and tolerability of panobinostat in the patient population. Finally, this study will look at the effect of panobinostat on Notch 1 signaling before and after treatment with panobinostat.

Enrollment

15 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically confirmed, metastatic, low grade neuroendocrine neoplasms. Small cell lung cancers, paragangliomas, and pheochromocytomas are excluded
Must have measurable disease as defined by RECIST
4 weeks from completion of major surgery, chemotherapy, or other systemic therapy or local liver therapy to study registration. Concurrent octreotide is allowed.
Not allowed to be on concurrent chemotherapy or radiation
18 years of age or older
ECOG Performance status of equal to or less than 2
Able to sign and date a written informed consent prior to participation in the study
Baseline MUGA or ECHO must demonstrate LVEF greater than or equal to the lower limit of the institutional normal
Must have the following laboratory criteria: Neutrophil count greater than 1500/mm3, platelet count greater than 100,000/mm3L, hemoglobin greater than or equal to 9 g/dL, AST/SGOT and ALT/SGPT less than or equal to 2.5 x ULN, serum bilirubin less than or equal to 1.5 x ULN, serum creatinine less than or equal to 1.5 x ULN, total serum calcium greater than or equal to LLN, serum potassium greater than or equal to LLN, serum sodium greater than or equal to LLN, serum albumin greater than or equal to LLN or 3g/dl,
Women of child bearing potential must have a negative urine pregnancy test within 72 hours of first administration of study treatment and must be willing to use two methods of contraception
Patients with a history of hypertension must be well controlled (to less than 150/90 mmHg) on a stable regimen of anti-hypertensive therapy

Exclusion criteria

Prior HDAC, DAC, HSP90 inhibitors or valproic acid for the treatment of cancer
Patients who will need valproic acid for any medical condition during the study or within 5 days prior to the first panobinostat treatment
Impaired cardiac function including any of the following: Screening ECG with a QTc greater than 450 msec, patients with congenital long QT syndrome, history of unsustained ventricular tachycardia, any history of ventricular fibrillation or torsades de pointes, bradycardia defined as heart rate less than 50 beats per minutes, patients with a myocardial infarction or unstable angina within 6 months of study entry, congestive heart failure, right bundle branch block or left anterior hemiblock
Uncontrolled hypertension
Unresolved diarrhea greater than CTCAE grade 1
Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral panobinostat
Other concurrent sever and/or uncontrolled medical conditions
Patients with a history of another primary malignancy that, in the opinion of the investigator, would interfere with the assessment of the primary endpoint of the study
Patients with known positivity for human immunodeficiency virus (HIV) or hepatitis C, baseline testing is not required
Any significant history of non-compliance to medical regimens or with inability to grant a reliable informed consent
Any medication which may cause QTc prolongation or inducing torsades de pointes
Use of concomitant medications that may interact with panobinostat