Study of Peripheral Arterial Disease (PAD) in People With Cancer Who Will Be Having Surgery

Memorial Sloan Kettering Cancer Center (MSK)

Status: Active, not recruiting

Conditions: Peripheral Arterial Disease (PAD) in Cancer Patients

Treatments: Diagnostic Test: ABI/TBI; Other: Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT05754944

22-326

Details and patient eligibility

About

Researchers are studying whether people with risk factors for blood circulation disease have a condition called peripheral arterial disease (PAD). People with PAD have poor blood circulation because of narrowing or blocks in blood vessels caused by fat or calcium deposits (atherosclerosis). The study researchers think that PAD may lead to worse outcomes in cancer treatment, but people with cancer are not routinely tested for the disease.

The purpose of this study is to find out how common PAD is among people with cancer who have risk factors for blood circulation disease, and to compare how often PAD is diagnosed in different racial groups

Enrollment: 114 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cancer patients who are ≥ 65 years old
• Either diabetes (on medication or insulin) or smoking history (current smoker, smoking within the last 15 years, ≥ 20 pack years)
• Patients who are scheduled for major head and neck, thoracic, abdominal, or pelvic surgery requiring at least a 2-day admission
• Ambulatory
• ≥ 6 month life expectancy as determined based on clinical judgement by the treating physician. If treating clinician does not confirm life-expectancy ≥ 6 months, will calculate Lee Schoenberg Index using ePrognosis.ucsf.edu.

Exclusion criteria

• Hospice patient, patient with a DNR order
• Non-ambulatory, wheelchair/bed bound
• < 6 month life expectancy based on the clinical judgement by the treating physician

Trial design

114 participants in 1 patient group

Cancer patients having surgery

Description:

This is a prospective cohort study where patients who are 65 years or older with either a history of diabetes (requiring medication or insulin) or smoking history (current smoker, smoker within the last 15 years, or ≥ 20 year pack history), facing major head and neck, thoracic, abdominal, or pelvic surgery will be screened for PAD with an ABI/TBI to establish prevalence and to compare prevalence among races to meet

Treatment:

Other: Questionnaires

Diagnostic Test: ABI/TBI