Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)

University of California San Francisco (UCSF)

Status: Completed

Conditions: Focus Groups

Study type: Observational

Funder types: Other

Identifiers

NCT00187668

701

Details and patient eligibility

About

Collect DNA from well-characterized healthy volunteers.

Full description

DNA and plasma will be used to identify and determine allele frequencies of genetic variants in membrane transporters and other genes relevant to human disease or drug response, including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease, asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve as the hypothesis-generating phase for future studies by identifying genetic variants and determining allele frequencies among an ethnically diverse cohort of healthy volunteers. Future investigations (separate IRB applications) will attempt to correlate genotypes to phenotypes among this cohort of volunteers. The allele identification and frequency data from this group of healthy volunteers will also be used to design association studies in relevant disease populations.

Determine if identified sequence variants are associated with gain or loss of in vitro biologic function using lymphocytes obtained from patients.

Enrollment: 500 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult subjects of both genders and specified ethnic groups
• Subjects must be between 18-40 years of age

Exclusion criteria

• Smokers
• Drink > 2 alcoholic beverages/day
• Take any chronic medication

Trial design

500 participants in 4 patient groups

African American

Description:

Must self identify as African American with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Cuacasian

Description:

Must self identify as Caucasian with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Hispanic

Description:

Must self identify as Hispanic with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.

Asian

Description:

Must self identify as Asian with parents and grandparents of the same ethnicity. Must be healthy taking no over the counter medications or prescription medications.