Study of Pituitary Size and Function in Familial Dwarfism of Sindh

National Center for Research Resources (NCRR)

Status: Completed

Conditions: Growth Hormone Deficiency

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00004365

NU-571

199/11940

Details and patient eligibility

About

OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan.

II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.

Full description

PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated.

All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.

Sex: All

Ages: 10 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Familial Dwarfism of Sindh
• Severe short stature but proportionate without dysmorphic features
• Normal body size and weight at birth
• Bone age is severely delayed
• Puberty is somewhat delayed (age 15-16)
• Fertility present in at least 3 dwarfs