Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure (PRA-MMP)

University of Monastir

Status: Completed

Conditions: Acute Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT02170961

PRA-MMP

Details and patient eligibility

About

this study aim to investigate the:

• association of RAAS polymorphisms and AHF
• association of MMP 3 and 12 polymorphisms and AHF

Full description

Heart failure can be defined as a complex clinical syndrome that results from any structural or functional disorder of the heart, with impairment of ability to fill the ventricles or eject blood. The main event of the IC is dyspnea and fatigue, which limit exercise tolerance and induces water retention.

The renin angiotensin aldosterone system governs the salt and water homeostasis in the body. Renin is a proteolytic enzyme secreted by the juxtaglomerular apparatus of the kidney (area near the glomeruli). Renin has no direct action on the organism, but that is part of the renin-angiotensin system or the renin-angiotensin-aldosterone system is known.

To date, few published studies have examined the association between the polymorphism AGT M235T * and cardiac dysfunction; and available results are contradictory. What is not known yet is the ratio of this polymorphism with the prognosis of heart failure.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged more than 18 year old.
• acute non traumatic dyspnea .

Exclusion criteria

• ECG diagnostic for acute myocardial infarction or ischemic chest pain within the prior 24 hours
• a history of a heart transplant, pericardial effusion, chest wall deformity suspected of causing dyspnea
• coma, shock,MV,vasopressor drugs
• arrhythmia serious and sustained,
• pace maker
• severe mitral valve disease,

Trial design

300 participants in 2 patient groups

acute heart failure (AHF)

Description:

patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data.

Non acute heart failure (NAHF)

Description:

patients consulting the emergency department for dyspnea. the diagnosis of AHF was based on clinical, biological (BNP) and echocardiographic data.